This thesis studied about whether people with differences in personality react differently to social uncertainty. Two domains of Big Five personality traits are examined: extraversion and neuroticism. 102 anonymous participants filled in online questionnaires which randomly assigned 51 participants to a hypothetical extravert partner in trust game while another 51 participants faced a hypothetical introvert partner. The result shows that trustor’s extraversion level does not affect ambiguity aversion, perception of others’ trustworthiness as well as the intensity of trust. On the other hand, neuroticism is found to have positive effect on perception of others’ trustworthiness, but no significant effect is found on ambiguity aversion and intensity of trust. However, trustee’s extraversion level is found to significantly affect trustor’s perception of others’ trustworthiness as well as the intensity of trust given by trustor.