This thesis analyses Deleuze’s ideas on cinema, focusing especially on ‘the brain is the screen’ and combines these with several more recent works on the topic in order to recontextualize it within our digital screen culture and new knowledge of the brain. It is argued that cinema has the ability to foster thought creating circuits, implying that cinema possesses plasticity just like our brain does. This plasticity is reinforced through the newfound screen multiplicity and technologies that currently surround cinema. The relation between brain and cinema can therefore be termed as diffractive, as it has the potential to create difference and by opening up the past, also opens the future.