Using WHO-CHOICE methodology, we found several established malaria interventions and the introduction of a vaccine and combinations thereof to be highly cost-effective (8-127 int$/DALY) in sub-Saharan Africa, where the malaria disease burden is highest. By means of Solow modeling, we estimate that continuous malaria suppression increases per capita income up to 50% compared to a non-intervention scenario after a time span of 65 years.